Novel Biophotonic Techniques for Phototherapy Enhancement: Cerenkov Radiation as a Bridge between Ionizing and Non-Ionizing Radiation Treatment

In oncology, tremendous research has been conducted on the use of alternative minimally invasive techniques for cancer treatment and diagnosis. The biophotonic as a standalone or together with conventional imaging gained interest among researchers in recent years, while therapies such photothermal photodynamic tend to bring non-ionizing radiation therapy back into spotlight due progressive development optical instrumentation, enhancement agents, molecular probes, light sources nanocarriers. Thus, coupling ionizing (IR) combination nanomedicine nuclear medicine procedures are considered be revolutionary strategies optimize therapeutic efficacy modalities develop theranostic applications better diagnosis cancer. Recently, low-intensity Cerenkov emitted by tissues byproduct IR–biostructure interaction suggested an effective internal source that can trigger phototherapy guide radiotherapy dosimetry using imaging. This review also provides overview vitro vivo studies regarding produced X-rays radionucleotides combined nanoparticles hybrid method induce enhanced therapies.